The Monadnock Building occupies the block bounded by Jackson, Dearborn, Federal and Van Buren Streets, across the street from the Federal Center and the Union League Club, in the Chicago Loop.

The Board of Trade, the Chicago Public Library, the Loop post office and the Chicago Bar Association are all nearby.

Parking is available in a modern self-park garage across Federal Street and at several other nearby facilities.

The Jackson station of the O'Hare Blue Line is next to the Monadnock. Stations for all of the other El and subway lines are within a block of the building.

Congress Parkway, which provides access to the expressway system, is one block south.